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Replica exchange Gaussian accelerated molecular dynamics: Improved enhanced sampling and free energy calculation

Through adding a harmonic boost potential to smooth the system potential energy surface, Gaussian accelerated molecular dynamics (GaMD) provides enhanced sampling and free energy calculation of biomolecules without the need of predefined reaction coordinates. This work continues to improve the accel...

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Detalhes bibliográficos
Publicado no:J Chem Theory Comput
Main Authors: Huang, Yu-ming M., McCammon, J. Andrew, Miao, Yinglong
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747702/
https://ncbi.nlm.nih.gov/pubmed/29489349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.7b01226
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