Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or down regula...

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Hlavní autoři: Pierrot, Nathalie, Tyteca, Donatienne, D'auria, Ludovic, Dewachter, Ilse, Gailly, Philippe, Hendrickx, Aurélie, Tasiaux, Bernadette, Haylani, Laetitia El, Muls, Nathalie, N'Kuli, Francisca, Laquerrière, Annie, Demoulin, Jean-Baptiste, Campion, Dominique, Brion, Jean-Pierre, Courtoy, Pierre J, Kienlen-Campard, Pascal, Octave, Jean-Noël
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2013
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628100/
https://ncbi.nlm.nih.gov/pubmed/23554170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202215
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