Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or down regula...

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Bibliographic Details
Main Authors: Pierrot, Nathalie, Tyteca, Donatienne, D'auria, Ludovic, Dewachter, Ilse, Gailly, Philippe, Hendrickx, Aurélie, Tasiaux, Bernadette, Haylani, Laetitia El, Muls, Nathalie, N'Kuli, Francisca, Laquerrière, Annie, Demoulin, Jean-Baptiste, Campion, Dominique, Brion, Jean-Pierre, Courtoy, Pierre J, Kienlen-Campard, Pascal, Octave, Jean-Noël
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628100/
https://ncbi.nlm.nih.gov/pubmed/23554170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202215
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