Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or down regula...

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Détails bibliographiques
Auteurs principaux: Pierrot, Nathalie, Tyteca, Donatienne, D'auria, Ludovic, Dewachter, Ilse, Gailly, Philippe, Hendrickx, Aurélie, Tasiaux, Bernadette, Haylani, Laetitia El, Muls, Nathalie, N'Kuli, Francisca, Laquerrière, Annie, Demoulin, Jean-Baptiste, Campion, Dominique, Brion, Jean-Pierre, Courtoy, Pierre J, Kienlen-Campard, Pascal, Octave, Jean-Noël
Format: Artigo
Langue:Inglês
Publié: WILEY-VCH Verlag 2013
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628100/
https://ncbi.nlm.nih.gov/pubmed/23554170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202215
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