Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty

Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both...

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Detalhes bibliográficos
Main Authors: Hendrickx, Aurélie, Pierrot, Nathalie, Tasiaux, Bernadette, Schakman, Olivier, Brion, Jean-Pierre, Kienlen-Campard, Pascal, De Smet, Charles, Octave, Jean-Noël
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774615/
https://ncbi.nlm.nih.gov/pubmed/24066134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074305
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