Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways, in particular the endosomal/lysosomal and proteasomal...

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Bibliografische gegevens
Gepubliceerd in:Front Cell Neurosci
Hoofdauteurs: Evrard, Caroline, Kienlen-Campard, Pascal, Coevoet, Mathilde, Opsomer, Rémi, Tasiaux, Bernadette, Melnyk, Patricia, Octave, Jean-Noël, Buée, Luc, Sergeant, Nicolas, Vingtdeux, Valérie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263093/
https://ncbi.nlm.nih.gov/pubmed/30524243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00435
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