Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways, in particular the endosomal/lysosomal and proteasomal...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Evrard, Caroline, Kienlen-Campard, Pascal, Coevoet, Mathilde, Opsomer, Rémi, Tasiaux, Bernadette, Melnyk, Patricia, Octave, Jean-Noël, Buée, Luc, Sergeant, Nicolas, Vingtdeux, Valérie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263093/
https://ncbi.nlm.nih.gov/pubmed/30524243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00435
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