Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways, in particular the endosomal/lysosomal and proteasomal...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Evrard, Caroline, Kienlen-Campard, Pascal, Coevoet, Mathilde, Opsomer, Rémi, Tasiaux, Bernadette, Melnyk, Patricia, Octave, Jean-Noël, Buée, Luc, Sergeant, Nicolas, Vingtdeux, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263093/
https://ncbi.nlm.nih.gov/pubmed/30524243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00435
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