Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty

Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both...

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Bibliographic Details
Main Authors: Hendrickx, Aurélie, Pierrot, Nathalie, Tasiaux, Bernadette, Schakman, Olivier, Brion, Jean-Pierre, Kienlen-Campard, Pascal, De Smet, Charles, Octave, Jean-Noël
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774615/
https://ncbi.nlm.nih.gov/pubmed/24066134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074305
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