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Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty
Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774615/ https://ncbi.nlm.nih.gov/pubmed/24066134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074305 |
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