Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty

Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both...

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Main Authors: Hendrickx, Aurélie, Pierrot, Nathalie, Tasiaux, Bernadette, Schakman, Olivier, Brion, Jean-Pierre, Kienlen-Campard, Pascal, De Smet, Charles, Octave, Jean-Noël
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774615/
https://ncbi.nlm.nih.gov/pubmed/24066134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074305
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