Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Telomeres, the ends of linear eukaryotic chromosomes, shorten due to incomplete DNA replication and nucleolytic degradation. Cells counteract this shortening by employing a specialized reverse transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telomeres....

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Détails bibliographiques
Auteurs principaux: Gupta, Amitabha, Sharma, Sushma, Reichenbach, Patrick, Marjavaara, Lisette, Nilsson, Anna Karin, Lingner, Joachim, Chabes, Andrei, Rothstein, Rodney, Chang, Michael
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2013
Sujets:
Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606089/
https://ncbi.nlm.nih.gov/pubmed/23335335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.149120
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