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Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
The mechanisms by which imbalanced dNTPs induce mutations have been well characterized within a test tube, but not in vivo. We have examined mechanisms by which dNTP imbalances induce genome instability in strains of Saccharomyces cerevisiae with different amino acid substitutions in Rnr1, the large...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3045583/ https://ncbi.nlm.nih.gov/pubmed/20961955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq829 |
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