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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

A balanced supply of deoxyribonucleoside triphosphates (dNTPs) is one of the key prerequisites for faithful genome duplication. Both the overall concentration and the balance among the individual dNTPs (dATP, dTTP, dGTP, and dCTP) are tightly regulated, primarily by the enzyme ribonucleotide reducta...

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Detalhes bibliográficos
Main Authors: Kumar, Dinesh, Viberg, Jörgen, Nilsson, Anna Karin, Chabes, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896522/
https://ncbi.nlm.nih.gov/pubmed/20215435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq128
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