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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
A balanced supply of deoxyribonucleoside triphosphates (dNTPs) is one of the key prerequisites for faithful genome duplication. Both the overall concentration and the balance among the individual dNTPs (dATP, dTTP, dGTP, and dCTP) are tightly regulated, primarily by the enzyme ribonucleotide reducta...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896522/ https://ncbi.nlm.nih.gov/pubmed/20215435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq128 |
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