A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication fidelity, it is not clear why certain dNTP pool al...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Gries, Kerstin, Gross, Maike, Zhao, Boyu, Yuan, Jui-Hung, Wade, Rebecca, Chabes, Andrei, Hombauer, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326808/
https://ncbi.nlm.nih.gov/pubmed/30462295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1154
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