A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication fidelity, it is not clear why certain dNTP pool al...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Gries, Kerstin, Gross, Maike, Zhao, Boyu, Yuan, Jui-Hung, Wade, Rebecca, Chabes, Andrei, Hombauer, Hans
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326808/
https://ncbi.nlm.nih.gov/pubmed/30462295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1154
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