A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication fidelity, it is not clear why certain dNTP pool al...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Gries, Kerstin, Gross, Maike, Zhao, Boyu, Yuan, Jui-Hung, Wade, Rebecca, Chabes, Andrei, Hombauer, Hans
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326808/
https://ncbi.nlm.nih.gov/pubmed/30462295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1154
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