A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication fidelity, it is not clear why certain dNTP pool al...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Gries, Kerstin, Gross, Maike, Zhao, Boyu, Yuan, Jui-Hung, Wade, Rebecca, Chabes, Andrei, Hombauer, Hans
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326808/
https://ncbi.nlm.nih.gov/pubmed/30462295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1154
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