Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

Eukaryotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch repair (MMR). Nucleotide selectivity and proofreading are affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are stri...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schmidt, Tobias T., Reyes, Gloria, Gries, Kerstin, Ceylan, Cemile Ümran, Sharma, Sushma, Meurer, Matthias, Knop, Michael, Chabes, Andrei, Hombauer, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465912/
https://ncbi.nlm.nih.gov/pubmed/28416670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618714114
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