Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

Eukaryotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch repair (MMR). Nucleotide selectivity and proofreading are affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are stri...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Schmidt, Tobias T., Reyes, Gloria, Gries, Kerstin, Ceylan, Cemile Ümran, Sharma, Sushma, Meurer, Matthias, Knop, Michael, Chabes, Andrei, Hombauer, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465912/
https://ncbi.nlm.nih.gov/pubmed/28416670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618714114
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