Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

Eukaryotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch repair (MMR). Nucleotide selectivity and proofreading are affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are stri...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Schmidt, Tobias T., Reyes, Gloria, Gries, Kerstin, Ceylan, Cemile Ümran, Sharma, Sushma, Meurer, Matthias, Knop, Michael, Chabes, Andrei, Hombauer, Hans
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465912/
https://ncbi.nlm.nih.gov/pubmed/28416670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618714114
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