Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

The mechanisms by which imbalanced dNTPs induce mutations have been well characterized within a test tube, but not in vivo. We have examined mechanisms by which dNTP imbalances induce genome instability in strains of Saccharomyces cerevisiae with different amino acid substitutions in Rnr1, the large...

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Hlavní autoři: Kumar, Dinesh, Abdulovic, Amy L., Viberg, Jörgen, Nilsson, Anna Karin, Kunkel, Thomas A., Chabes, Andrei
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045583/
https://ncbi.nlm.nih.gov/pubmed/20961955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq829
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