Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

The mechanisms by which imbalanced dNTPs induce mutations have been well characterized within a test tube, but not in vivo. We have examined mechanisms by which dNTP imbalances induce genome instability in strains of Saccharomyces cerevisiae with different amino acid substitutions in Rnr1, the large...

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Bibliographic Details
Main Authors: Kumar, Dinesh, Abdulovic, Amy L., Viberg, Jörgen, Nilsson, Anna Karin, Kunkel, Thomas A., Chabes, Andrei
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045583/
https://ncbi.nlm.nih.gov/pubmed/20961955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq829
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