Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

The integrity of the genome depends on diverse pathways that regulate DNA metabolism. Defects in these pathways result in genome instability, a hallmark of cancer. Deletion of ELG1 in budding yeast, when combined with hypomorphic alleles of PCNA results in spontaneous DNA damage during S phase that...

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Autori principali: Davidson, Marta B, Katou, Yuki, Keszthelyi, Andrea, Sing, Tina L, Xia, Tian, Ou, Jiongwen, Vaisica, Jessica A, Thevakumaran, Neroshan, Marjavaara, Lisette, Myers, Chad L, Chabes, Andrei, Shirahige, Katsuhiko, Brown, Grant W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280564/
https://ncbi.nlm.nih.gov/pubmed/22234187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.485
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