טוען...
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype
The integrity of the genome depends on diverse pathways that regulate DNA metabolism. Defects in these pathways result in genome instability, a hallmark of cancer. Deletion of ELG1 in budding yeast, when combined with hypomorphic alleles of PCNA results in spontaneous DNA damage during S phase that...
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| Main Authors: | , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280564/ https://ncbi.nlm.nih.gov/pubmed/22234187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.485 |
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