dNTP pools determine fork progression and origin usage under replication stress

Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased mutagenesis, genomic instability and tumourigenesis. However, the mechanisms by which altered or imbalanced dNTP pools a...

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Главные авторы: Poli, Jérôme, Tsaponina, Olga, Crabbé, Laure, Keszthelyi, Andrea, Pantesco, Véronique, Chabes, Andrei, Lengronne, Armelle, Pasero, Philippe
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280562/
https://ncbi.nlm.nih.gov/pubmed/22234185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.470
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