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dNTP pools determine fork progression and origin usage under replication stress

Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased mutagenesis, genomic instability and tumourigenesis. However, the mechanisms by which altered or imbalanced dNTP pools a...

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Bibliografske podrobnosti
Main Authors: Poli, Jérôme, Tsaponina, Olga, Crabbé, Laure, Keszthelyi, Andrea, Pantesco, Véronique, Chabes, Andrei, Lengronne, Armelle, Pasero, Philippe
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280562/
https://ncbi.nlm.nih.gov/pubmed/22234185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.470
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