dNTP pools determine fork progression and origin usage under replication stress

Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased mutagenesis, genomic instability and tumourigenesis. However, the mechanisms by which altered or imbalanced dNTP pools a...

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Autori principali: Poli, Jérôme, Tsaponina, Olga, Crabbé, Laure, Keszthelyi, Andrea, Pantesco, Véronique, Chabes, Andrei, Lengronne, Armelle, Pasero, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280562/
https://ncbi.nlm.nih.gov/pubmed/22234185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.470
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