Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Telomeres, the ends of linear eukaryotic chromosomes, shorten due to incomplete DNA replication and nucleolytic degradation. Cells counteract this shortening by employing a specialized reverse transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telomeres....

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Hlavní autoři: Gupta, Amitabha, Sharma, Sushma, Reichenbach, Patrick, Marjavaara, Lisette, Nilsson, Anna Karin, Lingner, Joachim, Chabes, Andrei, Rothstein, Rodney, Chang, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606089/
https://ncbi.nlm.nih.gov/pubmed/23335335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.149120
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