Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Telomeres, the ends of linear eukaryotic chromosomes, shorten due to incomplete DNA replication and nucleolytic degradation. Cells counteract this shortening by employing a specialized reverse transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telomeres....

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Detalhes bibliográficos
Main Authors: Gupta, Amitabha, Sharma, Sushma, Reichenbach, Patrick, Marjavaara, Lisette, Nilsson, Anna Karin, Lingner, Joachim, Chabes, Andrei, Rothstein, Rodney, Chang, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2013
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606089/
https://ncbi.nlm.nih.gov/pubmed/23335335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.149120
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