Spirocyclic replacements for the isatin in the highly selective, muscarinic M(1) PAM ML137: the continued optimization of an MLPCN probe molecule

This Letter describes the further optimization of an MLPCN probe molecule (ML137) through the introduction of 5- and 6- membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M(1) PAMs, are presented. These novel spirocy...

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Autors principals: Poslusney, Michael S., Melancon, Bruce J., Gentry, Patrick R., Sheffler, Douglas J., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594472/
https://ncbi.nlm.nih.gov/pubmed/23416001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.017
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