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Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells

Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized. These agents, 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (1) and N-(2-chloroethyl)-2-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (2), were des...

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Autors principals: Zhu, Rui, Baumann, Raymond P., Patridge, Eric, Penketh, Philip G., Shyam, Krishnamurthy, Ishiguro, Kimiko, Sartorelli, Alan C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594432/
https://ncbi.nlm.nih.gov/pubmed/23395657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.016
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