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Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells

Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized. These agents, 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (1) and N-(2-chloroethyl)-2-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (2), were des...

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Dettagli Bibliografici
Autori principali: Zhu, Rui, Baumann, Raymond P., Patridge, Eric, Penketh, Philip G., Shyam, Krishnamurthy, Ishiguro, Kimiko, Sartorelli, Alan C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594432/
https://ncbi.nlm.nih.gov/pubmed/23395657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.016
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