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Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells

Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized. These agents, 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (1) and N-(2-chloroethyl)-2-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide (2), were des...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Rui, Baumann, Raymond P., Patridge, Eric, Penketh, Philip G., Shyam, Krishnamurthy, Ishiguro, Kimiko, Sartorelli, Alan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594432/
https://ncbi.nlm.nih.gov/pubmed/23395657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.016
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