Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

OBJECTIVES: Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound daruna...

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Bibliografiske detaljer
Main Authors: Croteau, David, Rossi, Steven S., Best, Brookie M., Capparelli, Edmund, Ellis, Ronald J., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina M., McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, Letendre, Scott
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566670/
https://ncbi.nlm.nih.gov/pubmed/23143899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks441
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