Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

OBJECTIVES: Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound daruna...

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Bibliografische gegevens
Hoofdauteurs: Croteau, David, Rossi, Steven S., Best, Brookie M., Capparelli, Edmund, Ellis, Ronald J., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina M., McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, Letendre, Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566670/
https://ncbi.nlm.nih.gov/pubmed/23143899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks441
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