Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1

HIV-associated neurocognitive disorders continue to be common. Antiretrovirals that achieve higher concentrations in cerebrospinal fluid (CSF) are associated with better control of HIV and improved cognition. The objective of this study was to measure total raltegravir (RAL) concentrations in CSF an...

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Autores principales: Croteau, David, Letendre, Scott, Best, Brookie M., Ellis, Ronald J., Breidinger, Sheila, Clifford, David, Collier, Ann, Gelman, Benjamin, Marra, Christina, Mbeo, Gilbert, McCutchan, Allen, Morgello, Susan, Simpson, David, Way, Lauren, Vaida, Florin, Ueland, Susan, Capparelli, Edmund, Grant, Igor
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981289/
https://ncbi.nlm.nih.gov/pubmed/20876368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00507-10
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