Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

OBJECTIVES: Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound daruna...

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Detalhes bibliográficos
Main Authors: Croteau, David, Rossi, Steven S., Best, Brookie M., Capparelli, Edmund, Ellis, Ronald J., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina M., McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, Letendre, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566670/
https://ncbi.nlm.nih.gov/pubmed/23143899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks441
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