Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

OBJECTIVES: Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound daruna...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Croteau, David, Rossi, Steven S., Best, Brookie M., Capparelli, Edmund, Ellis, Ronald J., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina M., McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, Letendre, Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566670/
https://ncbi.nlm.nih.gov/pubmed/23143899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks441
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky