Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1

HIV-associated neurocognitive disorders continue to be common. Antiretrovirals that achieve higher concentrations in cerebrospinal fluid (CSF) are associated with better control of HIV and improved cognition. The objective of this study was to measure total raltegravir (RAL) concentrations in CSF an...

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Main Authors: Croteau, David, Letendre, Scott, Best, Brookie M., Ellis, Ronald J., Breidinger, Sheila, Clifford, David, Collier, Ann, Gelman, Benjamin, Marra, Christina, Mbeo, Gilbert, McCutchan, Allen, Morgello, Susan, Simpson, David, Way, Lauren, Vaida, Florin, Ueland, Susan, Capparelli, Edmund, Grant, Igor
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981289/
https://ncbi.nlm.nih.gov/pubmed/20876368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00507-10
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