Evaluation in vitro and in animals of a new (11)C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

Two allosteric modulators of the Group I metabotropic glutamate receptors (mGluR1 & mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1. METHODS: LY2428703, a full mGluR1 antagonist (IC(50) = 8.9 nM) and partial mGluR5 antagonist (IC(50) = 118 nM) and LSN2606428,...

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Main Authors: Zanotti-Fregonara, Paolo, Barth, Vanessa N., Liow, Jeih-San, Zoghbi, Sami S., Clark, David T., Rhoads, Emily, Siuda, Edward, Heinz, Beverly A., Nisenbaum, Eric, Dressman, Bruce, Joshi, Elizabeth, Luffer-Atlas, Debra, Fisher, Matthew J., Masters, John J., Goebl, Nancy, Kuklish, Steven L., Morse, Cheryl, Tauscher, Johannes, Pike, Victor W., Innis, Robert B.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537910/
https://ncbi.nlm.nih.gov/pubmed/23135321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-012-2269-7
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