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Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-...

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Detalhes bibliográficos
Main Authors: Tate, Barbara, McKee, Timothy D., Loureiro, Robyn M. B., Dumin, Jo Ann, Xia, Weiming, Pojasek, Kevin, Austin, Wesley F., Fuller, Nathan O., Hubbs, Jed L., Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536039/
https://ncbi.nlm.nih.gov/pubmed/23320246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/210756
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