Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

INTRODUCTION: Modulation of the gamma-secretase enzyme, which reduces the production of the amyloidogenic Aβ(42 )peptide while sparing the production of other Aβ species, is a promising therapeutic approach for the treatment of Alzheimer's disease. Satori has identified a unique class of small...

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Bibliographic Details
Main Authors:	Loureiro, Robyn M, Dumin, Jo Ann, McKee, Timothy D, Austin, Wesley F, Fuller, Nathan O, Hubbs, Jed L, Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S, Tate, Barbara
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2013
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3707052/ https://ncbi.nlm.nih.gov/pubmed/23597079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt173
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Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

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