Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-...

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Main Authors: Tate, Barbara, McKee, Timothy D., Loureiro, Robyn M. B., Dumin, Jo Ann, Xia, Weiming, Pojasek, Kevin, Austin, Wesley F., Fuller, Nathan O., Hubbs, Jed L., Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536039/
https://ncbi.nlm.nih.gov/pubmed/23320246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/210756
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