Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-...

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Autores principales: Tate, Barbara, McKee, Timothy D., Loureiro, Robyn M. B., Dumin, Jo Ann, Xia, Weiming, Pojasek, Kevin, Austin, Wesley F., Fuller, Nathan O., Hubbs, Jed L., Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536039/
https://ncbi.nlm.nih.gov/pubmed/23320246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/210756
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