Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

[Image: see text] A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1–42) (Aβ42) relative to Aβ40. This profile is...

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Autors principals: Findeis, Mark A., Schroeder, Frank, McKee, Timothy D., Yager, Debra, Fraering, Patrick C., Creaser, Steffen P., Austin, Wesley F., Clardy, Jon, Wang, Rong, Selkoe, Dennis, Eckman, Christopher B.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509716/
https://ncbi.nlm.nih.gov/pubmed/23205187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000857
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