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Small Molecule Amides as Potent ROR-γ Selective Modulators

The structure-activity relationship study of a diphenylpropanamide series of RORγ selective modulators is reported. Compounds were screened using chimeric receptor Gal4 DNA-binding domain (DBD)-NR ligand binding domain cotransfection assay in a two-step format. Three different regions of the scaffol...

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Detalhes bibliográficos
Main Authors: Khan, Pasha M., El-Gendy, Bahaa El-Dien M., Kumar, Naresh, Garcia-Ordonez, Ruben, Lin, Li, Ruiz, Claudia H., Cameron, Michael D., Griffin, Patrick R., Kamenecka, Theodore M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534870/
https://ncbi.nlm.nih.gov/pubmed/23232056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.025
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