Antiobesity Effect of a Small Molecule Repressor of RORγ

The orphan nuclear receptor RORγ is a key regulator for T helper 17 (T(H)17) cell differentiation, which regulates metabolic and circadian rhythm genes in peripheral tissues. Previously, it was shown that the small molecule inverse agonist of RORγ SR1555 [1-(4-((4′-(1,1,1,3,3,3-hexafluoro-2-hydroxyp...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Chang, Mi Ra, He, Yuanjun, Khan, Tanya M., Kuruvilla, Dana S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Unger, Thaddeus J., White, David W., Khan, Susan, Lin, Li, Cameron, Michael D., Kamenecka, Theodore M., Griffin, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468634/
https://ncbi.nlm.nih.gov/pubmed/25904554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097485
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