HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeutics to correct aberrant NR signaling or as chemical...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579513/
https://ncbi.nlm.nih.gov/pubmed/31172947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47172
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