HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeutics to correct aberrant NR signaling or as chemical...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2019
Onderwerpen:
Biochemistry and Chemical Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579513/
https://ncbi.nlm.nih.gov/pubmed/31172947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47172
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