Identification of potent RORβ modulators: Scaffold variation

We sought to develop RORβ-selective probe molecules in order to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiology of disease. To accomplish this, we modified a potent dual RORβ/RORγ inverse agonist from the primary literature with the goal of improving...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Doebelin, Christelle, Patouret, Rémi, Garcia-Ordonez, Ruben D., Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Novick, Scott, Ciesla, Anthony, Campbell, Sean, Solt, Laura A., Griffin, Patrick R., Kamenecka, Theodore M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238650/
https://ncbi.nlm.nih.gov/pubmed/30143422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.08.017
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