N-arylsulfonyl indolines as RORγ agonists

The nuclear receptor RORγ (NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (T(H)17) cell proliferation. As such, synthetic small molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various a...

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Publicado no:ChemMedChem
Principais autores: Doebelin, Christelle, Patouret, Rémi, Garcia-Ordonez, Ruben D., Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Kuruvilla, Dana S., Novick, Scott J., Lin, Li, Cameron, Michael D., Griffin, Patrick R., Kamenecka, Theodore M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158182/
https://ncbi.nlm.nih.gov/pubmed/27879053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600491
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