Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists

Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with mo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Bioorg Med Chem Lett
Autori principali: Lin, Hua, Doebelin, Christelle, Patouret, Rémi, Garcia-Ordonez, Ruben D., Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Bayona, Claudia Ruiz, Cameron, Michael D., Griffin, Patrick R., Kamenecka, Theodore M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893368/
https://ncbi.nlm.nih.gov/pubmed/29548571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.019
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi