Synthetic RORγt Agonists Enhance Protective Immunity

The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining transcription factor to initiate the differentiation program of T(H)17 and T(c)17 cells, cells that have demonstrated anti-tumor efficacy. RORγt controls gene networks that enhance immunity including increased IL17...

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Publicat a:ACS Chem Biol
Autors principals: Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Doebelin, Christelle, Garcia-Ordonez, Ruben D., Novick, Scott J., Kuruvilla, Dana S., Kamenecka, Theodore M., Griffin, Patrick R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178133/
https://ncbi.nlm.nih.gov/pubmed/26785144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00899
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