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Synthetic RORγt Agonists Enhance Protective Immunity
The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining transcription factor to initiate the differentiation program of T(H)17 and T(c)17 cells, cells that have demonstrated anti-tumor efficacy. RORγt controls gene networks that enhance immunity including increased IL17...
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Publicado no: | ACS Chem Biol |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5178133/ https://ncbi.nlm.nih.gov/pubmed/26785144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00899 |
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