Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists

Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with mo...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Lin, Hua, Doebelin, Christelle, Patouret, Rémi, Garcia-Ordonez, Ruben D., Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Bayona, Claudia Ruiz, Cameron, Michael D., Griffin, Patrick R., Kamenecka, Theodore M.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893368/
https://ncbi.nlm.nih.gov/pubmed/29548571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.019
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