HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeutics to correct aberrant NR signaling or as chemical...

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Vydáno v:eLife
Hlavní autoři: Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579513/
https://ncbi.nlm.nih.gov/pubmed/31172947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47172
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