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Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...

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Main Authors: Kireeva, Maria L, Opron, Kristopher, Seibold, Steve A, Domecq, Céline, Cukier, Robert I, Coulombe, Benoit, Kashlev, Mikhail, Burton, Zachary F
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/
https://ncbi.nlm.nih.gov/pubmed/22676913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11
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