Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...

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Hauptverfasser: Kireeva, Maria L, Opron, Kristopher, Seibold, Steve A, Domecq, Céline, Cukier, Robert I, Coulombe, Benoit, Kashlev, Mikhail, Burton, Zachary F
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/
https://ncbi.nlm.nih.gov/pubmed/22676913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11
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