Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...

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Hlavní autoři: Kireeva, Maria L, Opron, Kristopher, Seibold, Steve A, Domecq, Céline, Cukier, Robert I, Coulombe, Benoit, Kashlev, Mikhail, Burton, Zachary F
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/
https://ncbi.nlm.nih.gov/pubmed/22676913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11
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