Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...

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Main Authors: Kireeva, Maria L, Opron, Kristopher, Seibold, Steve A, Domecq, Céline, Cukier, Robert I, Coulombe, Benoit, Kashlev, Mikhail, Burton, Zachary F
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/
https://ncbi.nlm.nih.gov/pubmed/22676913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11
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