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Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...

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Bibliografiske detaljer
Main Authors: Kireeva, Maria L, Opron, Kristopher, Seibold, Steve A, Domecq, Céline, Cukier, Robert I, Coulombe, Benoit, Kashlev, Mikhail, Burton, Zachary F
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/
https://ncbi.nlm.nih.gov/pubmed/22676913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11
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