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Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase
BACKGROUND: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile “trigger loop” of the catalytic subunit closes on the nucleoside triphosphate (NTP) substrate. Cl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533926/ https://ncbi.nlm.nih.gov/pubmed/22676913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2046-1682-5-11 |
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