Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

Molecular dynamics simulation of Thermus thermophilus (Tt) RNA polymerase (RNAP) in a catalytic conformation demonstrates that the active site dNMP-NTP base pair must be substantially dehydrated to support full active site closing and optimum conditions for phosphodiester bond synthesis. In silico m...

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Detalhes bibliográficos
Main Authors: Seibold, Steve A., Singh, Badri Nath, Zhang, Chunfen, Kireeva, Maria, Domecq, Céline, Bouchard, Annie, Nazione, Anthony M., Feig, Michael, Cukier, Robert I., Coulombe, Benoit, Kashlev, Mikhail, Hampsey, Michael, Burton, Zachary F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922424/
https://ncbi.nlm.nih.gov/pubmed/20478425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2010.05.002
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