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Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase
Molecular dynamics simulation of Thermus thermophilus (Tt) RNA polymerase (RNAP) in a catalytic conformation demonstrates that the active site dNMP-NTP base pair must be substantially dehydrated to support full active site closing and optimum conditions for phosphodiester bond synthesis. In silico m...
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| Glavni autori: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922424/ https://ncbi.nlm.nih.gov/pubmed/20478425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2010.05.002 |
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